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Biometals 38 , 18811895 (2025)

When to Be Concerned In a research context, further evaluation may be warranted if observations include: Rapidly expanding redness beyond the injection site Severe or escalating pain Persistent swelling lasting multiple days Signs of infection (increasing warmth, spreading redness, discharge) Systemic symptoms such as generalized hives, shortness of breath, dizziness, or facial swelling Severe or systemic reactions should be treated as medically significant and require appropriate clinical evaluation

Typical murine plasma half-life: 4-8 hours after subcutaneous injection (vs 10-20 minutes for native IGF-1)

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Jin SH, Yang JH, Shin BY, Seo K, Shin SM, Cho IJ, Ki SH