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Activated mutant FGFR3 (aFGFR3) upregulates the expression of key SSP enzymes such as PHGDH and PSAT1 through downstream signaling pathways, promoting intracellular de novo serine synthesis in bladder cancer cells ( Specifically, elevated serine synthesis subsequently activates the PI3K/Akt pathway in tumor-associated macrophages, shifting macrophages toward an immune-inert phenotype

[DOI] [PubMed] [Google Scholar] 131.Baeza-Morales A., Pascual-Garca S., Martnez-Peinado P., Navarro-Sempere A., Segovia Y., Medina-Garca M., Pujalte-Satorre C., Garca M., Martnez-Espinosa R.M., Sempere-Ortells J.M

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The expression of Peroxiredoxin 2 (Prx II), a member of the Peroxiredoxin (Prxs) family, was upregulated in psoriatic skin tissue [13]

However, the mechanism by which GSTU16 participates in this response still needs to be addressed

A biodistribution study revealed that the accumulation of DOX in tumors was over twice as high in the DOX/LAAM GSH-CQD group compared to any other organs, whereas free DOX was mainly distributed in the liver, and the fluorescence intensity of the tumor was only half that of the liver at this time point (Fig