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A major drawback in CD research has been the lack of a reliable and reproducible animal model, with the possible exception of the Irish setter dog, which may develop a gluten-related disease [15]

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In addition, sorbitol dehydrogenase in granulosa cells reduces glucose to form sorbitol, which is then fed by oocytes indirect fructose synthesis (40)

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SPSS version 22.0 (IBM, Armonk, NY, USA) was used for the statistical analyses