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This work was supported by the National Natural Science Foundation of China (grant numbers 82200699 to XC, and 82273560 to LJ), the Yunnan Provincial Science and Technology Program (grant number 202502AS100004 to XW), and the Ningbo City Public Welfare Research Plan Project (grant number 2024S038 to LJ)

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The supplement guides are equally applicable to researchers using either cagrilintide or retatrutide