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These restrictions and warnings demonstrate the FDAs stringent consideration of patient safety in the drug approval process

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Cancer Cell 11(6):539554 Feng M et al (2016) Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer

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These substances are used in small doses (mostly 1 mg anastrozole, 2.5 mg letrozole, and 12.5 mg exemestane)