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In 3T3-L1 cells, expression of TGH is upregulated tenfold upon differentiation of preadipocytes into adipocytes (25) due, at least in part, to transcriptional regulation by the adipogenic transcription factor C/EBP (136)

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Sci Rep 13 , 16519 (2023)

FOXO4-DRI represents a peptide-based senolytic approach that is more targeted than small-molecule senolytics like dasatinib plus quercetin, which affect broader cellular pathways