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Patients' exclusion criteria for Groups 1 and 2 were as follows: Pregnancy or unwilling for birth control History of blood or red blood cell (RBCs) transfusion over the past 3-months Hepatic or renal impairment Presence of co-morbid chronic infection or inflammation (unrelated to the disease as SLE or rheumatoid arthritis) History of hypersensitivity to hydroxycarbamide or L-Carnitine

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LeBleu, V

222 While rapidly dividing cells, such as activated T lymphocytes, predominantly rely on aerobic glycolysis for energy generation, 223,224 the specific energy derivation mechanism in GC B cells remained unclear until recent studies

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Acknowledgments We thank the patient and his family for their participation in the study