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2008 Jan;294(1):E131-41

Melanotan Peptides Melanotan I and Melanotan II are synthetic peptides that stimulate melanin production, leading to skin darkening

However, these preclinical findings do not establish safety for use during human pregnancy, as species differences in placental transfer and fetal metabolism may exist

Other representative dosages of a compound or a pharmaceutical composition of the present invention include about 1 mg/kg, 5 mg/kg, 10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg, 30 mg/kg, 35 mg/kg, 40 mg/kg, 45 mg/kg, 50 mg/kg, 60 mg/kg, 70 mg/kg, 80 mg/kg, 90 mg/kg, 100 mg/kg, 125 mg/kg, 150 mg/kg, 175 mg/kg, 200 mg/kg, 250 mg/kg, 300 mg/kg, 400 mg/kg, 500 mg/kg, 600 mg/kg, 700 mg/kg, 800 mg/kg, 900 mg/kg, or 1000 mg/kg

pBMMs were lysed in 500L cold water at hours 2, 6, 7, and 8 and plated for CFU

This is an important transaction because it detoxifies harmful chemicals, drugs, and hormone metabolites