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In the co-culture system, MCECs derived from the model group exhibited significant reduced ZO-1 and Occludin expression compared to those from the Control group, whereas GHK-Cu elevated theses protein levels (Figures 4GI)

Inhibition of cell growth was accompanied by cell cycle arrest, elevation in the levels of the tumor suppressors p21 and p27 and cellular senescence as well as induction of apoptosis

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15,16 Histological features observed in our patients align with the features reported in the literature on immunocompetent patients