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Moderation is always the key

Targeting mitochondrial function holds great promise for the dual prevention of CVDs and cognitive decline

Perhaps it is not surprising that docosahexaenoic acid, a supplement that phosphorylates nNOS (i.e., inhibits nNOS activity) protects dopaminergic neurons from MPTP toxicity in rodent models of PD 15

Rescue of FAO in TECs via overexpression of PGC1 or treatment with the PPAR agonist fenofibrate prevents histopathological progression of nephropathy in mouse models of kidney fibrosis (95)