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Collectively, these calcium-dependent effects in endothelial cells, VSMCs, and cardiac neural crest cells may contribute to the congestive heart failure frequently observed in patients with HHcy, although this is a multifactorial condition and direct causality remains complex to establish

Subcellular fractionation NE-PER TM nuclear and cytoplasmic extraction reagents (Life Technologies, CA, USA) were used for nuclearcytoplasmic fractionation in accordance with the manufacturers protocol

Seldenrijk (Department of Pathology), R

The risk of developing severe side effects is very low with only 1 in 500 patients experiencing serious adverse events and the potential benefits of the treatment are very high, especially for those who have found that no other treatments are effective