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Epidemiological studies indicate that the westernization of diet conveys a risk of developing inflammatory bowel disease (IBD)

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In view of the pivotal role played by GSH in redox system and the relationship between oxidative stress and autophagy 68 , it is conceivable that GSH depletion-induced oxidative stress and lipid peroxidation may be a key point linking ferroptosis and autophagy in RPE cells

DCs activated in the presence of rapamycin are better able to induce the primary expansion of CD8 + T cells in response to LPS plus OVA antigen, as well as the later establishment of a memory CD8 + T-cell population, compared to DCs without rapamycin treatment 50

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Copper-doped carbon dots (Cu-CDs) exploit this weakness by selectively targeting metallothionein-2 (MT-2), a key antioxidant protein