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Bioinformatics and environmental data analysis

Neurodegenerative diseases are characterized by progressive neuron losses in specific brain regions that impact cognitive, sensory, and motor functioning

Murakami and Kudo, 2002

doi: 10.1073/pnas.2109256118 21 DuanS.LiH.WangF.LiL.FanH.MaY.et al

These autophagosomes subsequently fuse with lysosomes to form autolysosomes, where the sequestered contents are degraded to meet cellular metabolic needs and facilitate organelle turnover (Luo and Tao, 2020)

More important, H 2 O 2 diffuses into the cytosol where it continues to activate ASK1/2 and, thus, JNK, which causes ROS release from complex I, and the cycle begins again, augmented by ROS from complex III, especially if NAPQI is still being formed ( Figure 16 & 17 )