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The IC50 of each compound was determined using GraphPad Prism 5 Software following a sigmoidal dose response curve for variable slope

This suggests that the homeostatic unbalance caused by ATG5 deficiency in replete LEC is likely not a direct consequence of obvious defects in canonical mitochondrial degradation pathways

380 FINO2 indirectly inhibits GPX4 activity (unlike Erastin and RSL3) without depleting GPX4 protein (unlike FIN56), while also oxidizing iron to drive ferroptosis

Panda pays for analytical testing, but Janoshik is not owned by, affiliated with, or compensated based on the findings reported in any certificate

Hum Mol Genet 2004

The rate of infusion can be slowed in order to decrease negative symptoms