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3.1.1 Increased gut permeability During ischemia, the absence of blood flow produces hypoxia and cellular injury within the intestinal epithelial cells, leading to disruption of tight junction proteins such as occludin, claudins, and zonula occludens (Abdullahi et al., 2018)

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It is also manifested as a decrease in glutathione peroxidase 4 (GPX4), the core enzyme in the glutathione (GSH) antioxidant system (Chen et al

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Active Ingredients: Niacinamide and Vitamin C help even out skin tone while restoring brightness and healthy radiance

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