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Both doses led to an increase in maximal respiration and ATP-linked respiration in HC cells, while mitochondrial biogenesis and oxidative phosphorylation gene expression remained unchanged, suggesting that UA specifically enhances mitochondrial respiration to improve chondrocyte metabolic function

Other sources of ROS, primarily H 2 O 2 , are microsomes and peroxisomes

Intestinal permeability and mucosal tight junction proteins provide important epithelial barriers and have been shown to play key roles in the pathogenesis of diarrhea and constipation [62, 63]

Antioxidants Accelerate the Growth and Invasiveness of Tumors in Mice Evidence from two new studies in mice shows that antioxidantsdietary supplements commonly used in the belief that they may help prevent diseasemay actually promote tumor growth and metastasis

Doi: 10.1016/j.toxlet.2009.08.014 Ali I, Damdimopoulou P, Stenius U, Halldin K

Unilateral transtibial prosthesis users load their intact limb more than their prosthetic limb during sit-to-stand, squatting, and lifting