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Microneedling works on the skin barrier directly, creating controlled micro injuries that push the skin to rebuild itself with fresh collagen

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Anti-VCAM-1 and Anti-IL4R aptamer-conjugated super paramagnetic iron oxide nanoparticles for enhanced breast cancer diagnosis and therapy

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doi: 10.1016/j.crohns.2011.08.012

worked on the pH-responsive biodegradable chitosan nanogels incorporated with 0.1% and 0.2% 5-FU, and the developed formulation was applied topically on the Swiss albino male mice bearing skin cancer and compared with the control