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Accessed 21 May 2019 Wambaugh JF, Hughes MF, Ring CL et al (2018) Evaluating in vitroin vivo extrapolation of toxicokinetics

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doi: 10.1681/ASN.2012050536 78 ArnoldRIssarTKrishnanAVPussellBA

Abstract Background The logarithmic acid dissociation constant pKa reflects the ionization of a chemical, which affects lipophilicity, solubility, protein binding, and ability to pass through the plasma membrane

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