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10.1016/j.prostaglandins.2012.03.003 52 TrerotolaM.CantanelliP.GuerraE.TripaldiR.AloisiA

Multiple injury models, including optic nerve crush, traumatic brain injury, ischemic stroke, and hyperglycemia-induced neurotoxicity, have consistently demonstrated NRN1s ability to reduce neuronal apoptosis (Sharma et al., 2015

The rate of diffusion is inversely proportional to the square of the distance (double the distance, quadruple the time), and in biological terms, since most cell lipid membranes are of similar thickness, distance translates to the number of cell layers

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Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems