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Whereas, aldehyde-reactive alkoxyamines capture AP sites, and inhibit the activity of APE1, the enzyme responsible for base excision repair (BER)

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While cardiac functions were not assessed in this study, it is possible that the improvements in RV and other lung function parameters noted with nebulized GLY may be associated with improvements in cardiac function, similar to other trials

The primary pathways through which chronic inflammation contributes to renal aging have been elaborated in previous studies

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A recent study reported that activation of AMPK1 promoted PASMCs proliferation [23]