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This isnt your average anti-aging fluff

All data is sourced from published preclinical and clinical research for educational reference only

FEBS Lett 447, 303306 (1999)

HCA1, previously known as the orphan G protein-coupled receptor 81 (GPR81), is coupled to G i protein and downregulates cAMP production

In humans, UC patient biopsies exhibited increased H4R RNA and protein expression over control tissue, and immunohistochemistry showed that H4R was in proximity to immunopathogenic myeloperoxidase-positive neutrophils