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Dogs taking the supplement, which provided 225 mg of SAMe and 82 mg of silybin-phosphatidylcholine complex (24 mg of silybin) per day, throughout chemotherapy were less likely to exhibit increased biomarkers of liver damage and were less likely to have their chemotherapy treatments delayed due to increased liver enzyme activity

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PubMed PMID: 21699455

The study was supported by a grant from The Faroese Research Council

In some clinical studies, a lower dose of 37.5 mg twice daily was used to good effect

Abstract Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization