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Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death

Duan J, Chen C, Li H, Ju G, Gao A, Sun Y, Zhang W

PCs are non-ribosomally synthesized from GSH (-Glu-Cys-Gly) by phytochelatin synthases (PCSs)

Serine biosynthesis is a metabolic vulnerability in FLT3-ITD-driven acute myeloid leukemia

Hepatocellular senescence induces multiorgan senescence and dysfunction via TGF