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Whereas, GPX3 overexpression could largely reverse the effect of RSL3 on activating ferroptosis via upregulating Nrf2 and GPX4

Pulmonary disease following respirator therapy of hyaline-membrane disease

In summary, GA inhibited the RhoA/CDC42 and PI3K-Akt-ERK1/2 pathways and activated the AMPK-eNOS-FAS signaling pathway, thereby suppressing the migration and proliferation of VSMCs (Figure 3)

10.1038/s41598-019-51648-1 231

Even though gemcitabine has significant therapeutic efficacies in treatment of some cancer patients, its clinical applications are limited by resistance