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doi: 10.1016/j.jaci.2003.09.015 116 HongSNRheeCSKimJKParkSKHanDH

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The activation of TLR4 causes a cascade of inflammatory signaling pathways, including the nuclear factor kappa B (NF-B) pathway, which leads to the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF- ), interleukin-1 (IL-1), and interleukin-6 (IL-6)

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The reduction in blood flow within spiral arterioles triggers vasoconstriction which causes local ischemia