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Growing evidence indicates that targeting these metabolic dependencies may offer therapeutic benefit, whether through dietary approaches like the ketogenic diet, pharmacologic inhibition of glycolysis and glutaminolysis, or disruption of mitochondrial activity and hypoxia/angiogenesis pathways

Year : 2016 Nitric Oxide and ERK Mediates Regulation of Cellular Processes by Ecdysterone Cite this Research Publication : A

Mechanistically, SOX2 expression is regulated by the PI3K/AKT signaling pathway, and the PI3K/AKT/SOX2 axis modulates the p53/p21/CDK2 pathway, thereby influencing cellular senescence [31]