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Two phase 2 trials, including older adults up to 75 years, have recently been published assessing the impact of retatrutide on patients with overweight and obesity, with or without T2D, respectively [75, 118]

Following the cumulative addition of BPC 157 at high concentration such as 10 or 100 g/ml, a slightly increased vasorelaxation in aorta without endothelium was noticed which deserved further investigation (Fig