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Cagrilintide is a long-acting analog of amylin (islet amyloid polypeptide), a pancreatic hormone co-secreted with insulin that induces satiety

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Cagrilintides longer measured half-life (roughly 78 days versus about 5 days for tirzepatide) is a pharmacokinetic fact from its own study not evidence of a better outcome

These unique structural features, particularly the way it engages with the receptors, are proposed to contribute to its potent and long-acting clinical efficacy as a dual agonist for weight management

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The pattern is consistent: wherever there is an approved, completed human RCT in this pair, it belongs to tirzepatide