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The clinical symptoms of functional constipation mainly include difficulty defecating, reduced frequency of defecation and dry stool ( Polysaccharides, as a class of natural macromolecular compounds with a variety of biological activities, are widely found in plants, animals and microorganisms ( Dendrobium officinale polysaccharide was proved to exert laxative effect through enhancing the gastrointestinal transit ratio, regulating gastrointestinal hormone levels and increasing fecal water content in constipated mice ( Gastrodia elata Blume polysaccharide significantly increased the abundance of probiotics (such as Bifidobacterium , Collinsella , Prevotella , and Faecalibacterium ) and inhibited the growth of pathogenics (such as Shigella , Dorea , Desulfovibrio , and Blautia ) to regulate the gut microbiota

270 The gut microbiota plays a significant role in influencing the health and disease status of the host

Internal healing or wounds in hard-to-reach areas require injectable

doi: 10.1038/nrd.2017.162 10 GulerRBrombacherF

doi:10.1152/ajpendo.1997.273.1.E185

However, the use of antioxidants in combination with such therapies may be counterproductive when the anticancer mechanism relies on ROS-mediated cell death