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Bringing the Heavy: Carbon Ion Therapy in the Radiobiological and Clinical Context

Due to the conformational differences between the P72 and R72 missense mutants, we speculated that their propensity for rescue by p53 targeting drugs, such as APR-246, may differ in that mutants with the P72 SNP would exhibit increased sensitivity

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Pedrote et al (68) revealed that accumulation of amyloid-like p53 with p53 gain of function phenotype leads to increased chemo-resistant GBM cells

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All these findings confirm that the gastrointestinal tract and lungs are complex organ systems that together maintain homeostasis within the body