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PD patients often exhibit gut dysbiosis, characterized by an increase in Akkermansia and decreases in Faecalibacterium and Roseburia [33]

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Additionally, GHK-Cu increases the expression of lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers, thereby reinforcing the three-dimensional architecture of the extracellular matrix

Following the sensing step, the cytoplasmic receptors/adaptors are activated to induce the downstream signaling transduction