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They used a toxic compound called menadione to stress the cells, and in the face of that stress the younger cells lost significantly less of their glutathione than older cells did

Neurons constantly fire electrical signals and maintain ion gradients that require large amounts of ATP

The activation of p38 is induced in the cardiomyocytes of symptomatic DUSP1/DUSP4 dKO mice

Ainslie, W

Furthermore, to enhance the impact of HCQ, novel approaches like incorporating carbon monoxide (CO) to increase the effectiveness of autophagy inhibitors and developing new polymer forms of HCQ (PCQ) have been explored [103, 104]

Future work will exploit these interactions to design selective PINK1 chemical probes