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Ideal candidates are research models with metabolic dysfunction characterized by both impaired insulin sensitivity and elevated adipose tissue NNMT expression common in diet-induced obesity, age-related metabolic decline, and type 2 diabetes models

Competing interests The authors stated no conflict of interest

Ann Neurol 2001;49:195-201 14

(2005) In vitro percutaneous absorption of pine bark extract (Pycnogenol) in human skin

Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis

Animal experiments also demonstrated that lipid peroxidation has a role in the pathogenesis of the early stages of OA