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Peroxyl radicals (ROO) constitute another class of oxygen-derived FRs

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IRE1 binds to TNF receptor-related factor 2 (TRAF2) to trigger caspase-12, which activates apoptotic factor caspase-3, and finally activates JNK signaling pathway to play the role of apoptosis (Martucciello et al., 2020)

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