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PLoS One 9 (11), e111755

However, the precise mechanisms underlying the initiation and execution of ferroptosis remain elusive, as well as the downstream signaling molecules and pathways involved in mediating the progression of PF [150]

4 Nrf2 binds antioxidant response elements (AREs) and induces phase II detoxification enzymes, including glutathione S transferases (GSTs), nicotinamide adenine dinucleotide (phosphate) hydrogen [NAD(P)H] quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), and enzymes for GSH synthesis

Free radicals and antioxidants quo vadis