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Results TDP-43 is SUMOylated in the nucleus in a context specific manner Various acute stressors including oxidative (sodium arsenite, NaAsO 2 ), hyperosmotic (D-sorbitol and sodium chloride), and heat shock have been demonstrated to induce TDP-43 mislocalization and aggregation in vitro , helping to uncover key mechanisms affected in disease[24, 58, 59]

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Effect of cannabis in combination with antidepressant drugs The immobility time in mice co-administered with fluoxetine (20 mg/kg, s.c.) and cannabis (5 mg/kg, s.c.) was significantly increased compared with the vehicle control group as well as with the cannabis only-treated group

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10.1021/acs.biochem.2c00488 [DOI] [PMC free article] [PubMed] [Google Scholar] Singer H, Steudtner R, Klein A, Rulofs C, Zeymer C, Drobot B, Pol A, Martinez-Gomez NC, den Camp HO, & Daumann L (2022)

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