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Expert Rev Gastroenterol Hepatol 2010;4(2):191-215

Active IRE1 processes the unspliced X-box binding protein 1 ( uXBP1 ) mRNA, producing the active transcription factor spliced XBP1 (sXBP1), which regulates genes involved in protein folding and ER-associated degradation [9]

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Excitotoxicity causes massive calcium influx, activating calcium-dependent proteases and NOS, which rapidly trigger MMP-9 activation, leading to the swift degradation of tight junctions and the basement membrane (166)

Instead, it reflects a broader collapse of ubiquitin-centered regulatory networks that integrate proteostasis, signaling, inflammation, and neuronal function

4C, compare lanes 7 to 5, and Fig