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Flubendazole, an antimalarial drug, inhibits SLC7A11/GPX4, promoting ferroptosis in castration-resistant prostate cancer ( via decreasing oxidized glutathione ( 4 Targeting PTMs as a Perspective Strategy Recently, a new generation of anticancer agents targeting PTMs has led to a revolutionary therapeutic approach that provides enhanced selectivity and context-specificity

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Each protein is characterized by a precise sequence of amino acid "bricks"

In addition, several other genes have been discovered to influence ferroptosis-related diseases by regulating factors associated with ferroptosis

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In mouse models of melanoma metastasis, G6PD deficiency decreases circulating melanoma cells and the metastatic burden 149