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The University of Michigan also warns that a B12 shot is not recommended for people with Lebers disease (7)

Insulin resistance, hyperinsulinemia, dyslipidaemia, and obesity precede the progression to T2D in 7585 % of patients [65], and the presence of MetS increases up to fivefold the risk for T2D compared to individuals without MetS [66, 67]

Since B12 is processed in the liver, excessive amounts could potentially lead to complications in severe liver conditions

Campdesuner V, Teklie Y, Alkayali T et al