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Supplemental short-acting opioids may be used as methadone levels accumulate, especially for patients previously utilizing fentanyl (e.g., oxycodone 10-20 mg titrated to effect)

B-Vitamins (B1, B2, B3, B5, B6) drive cellular energy production and support the nervous system

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Notably, while S1PR2 is upregulated and induces the internalization of meningococci, the activation of S1PR1 or S1PR3 reduces the number of intracellular bacteria (Fohmann et al., 2023)

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Lastly, the heightened activity of the glucose monophosphate shunt results in excessive NADPH consumption, thereby depleting the cofactor necessary for the synthesis of glutathione (GSH)