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88 Similarly, IL-13 the T-helper type 2 cytokine and key effector of ulcerative colitis also affects intestinal epithelial cell TJ function as well as apoptosis, 89 and was recently shown to regulate claudin-2 transcription in a signal transducers and activators of transcription-dependent manner

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Patients with severe reactions to PEGylated liposomes have been reported to have anti-PEGIgG titers approximately six times higher than those of non-reactive patients, and patients with anti-PEGIgG titers three times higher than the detection limit are approximately three times more likely to have more severe allergic reactions than those with anti-PEGIgG titers only one time higher than the detection limit

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[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Sampson T.R., Challis C., Jain N., Moiseyenko A., Ladinsky M.S., Shastri G.G., Thron T., Needham B.D., Horvath I., Debelius J.W., et al