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For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24

DOI: 10.1101/sqb.2012.76.010470 Lamia, K.A., Papp, S.J., Yu, R.T., Barish, G.D., Uhlenhaut, N.H., Jonker, J.W., Downes, M., Evans, R.M

Data availability A total of 262 studies analyzed in this study were identified through ClinicalTrials.gov, the International Clinical Trials Registry Platform, Cochrane Central Register of Controlled Trials, PubMed, and Web of Science

Some patients schedule regular treatment sessions to stay on track, while others pop in when they need a quick pick-me-up

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