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The enrichment of NF-B, a key transcription factor, regulates the expression of many immune-related factors, thus initiating the immune response

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Using CRISPR-Cas9 in human and mouse cells, genome-wide, targeted loss-of-function pooled screens have been studied that has provided information about the inactivated genomic loci and strategies that modulate transcriptional activities (Shalem et al., 2015)

Although present at 20 times higher activity than hexokinase, PFK-1 is strongly inhibited by ambient ATP, so that its activity varies with the energy status of the cell

doi: 10.3324/haematol.2018.193128 111 KirDSalujaMModiSVenkatachalamASchnettlerERoySet al