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For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51

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The body has learnt how to defend itself from these wayward molecules by producing endogenous antioxidants, and by drawing on protective compounds provided by the diet, such as vitamins C and E

In addition to the microbiota itself, intestinal fungi inhibit bacterial colonization by producing alcohol, antibacterial peptides, and some metabolites 145,146