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Monitoring substantia nigra degeneration using free water imaging across prodromal and clinical Parkinsons disease

10.1186/s12964-020-00637-3 54 GurungP.LukensJ

Disclosures: Jan Clusmann: Nothing to Disclose, Paul-Henry Koop: Nothing to Disclose, David Zhang: Nothing to Disclose, Felix Van Haag: Nothing to Disclose, Omar el Nahhas: Nothing to Disclose, Kai Markus Schneider: Nothing to Disclose, Jakob Nikolas Kather: Nothing to Disclose, Carolin Victoria Schneider: Nothing to Disclose 1934 WILMS TUMOR 1 AND HIF-1 INDUCE HEPATIC STELLATE CELL INVASION THAT DEVELOPS BRIDGING FIBROSIS IN CHRONIC LIVER INJURY Michitaka Matsuda 1 Tatsuya Kanto 1 Ekihiro Seki 2 , 1 National Center for Global Health and Medicine, 2 Cedars-Sinai Medical Center Background: Chronic liver injury induces the production and deposition of extracellular matrix (ECM) and its further remodeling develops Bridging fibrosis (BF)

Many mammalian studies have shown that only l-carnitine has beneficial effects ( Reference Liedtke, Nellis and Whitesell 16 Reference Spasov, Iezhitsa and Pisarev 18 ) , while d-carnitine can interfere with the uptake and transport of l-carnitine ( Reference Vernez 13 , Reference Paulson and Shug 19 ) , and therefore inhibit the -oxidation of FA ( Reference Spasov and Iezhitsa 20 , Reference Leichter, Ottem and Hahn 21 ) , which has a hepatotoxic effect ( Reference Arafa 22 )

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Recent studies have shown that Res synergises with ascorbic acid to preserve ovarian extracellular matrix components (e.g., collagen and the GAG network) and improve follicular survival [107]