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Animal studies have shown that the selective small-molecule inhibitor 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), targeting the key glycolytic enzyme Phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3), disrupts T cell metabolism, culminating in reduced cell proliferation and heightened cell death rates

A broad number of studies have demonstrated the reduction of glucose uptake in the brain of AD patients, and, in agreement, positron emission tomography (PET) scanning shows a consistent reduction of cerebral glucose consumption in the brain of AD patients (390, 391)

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10.1007/978-981-19-5860-1_1 163 KatreD.ChoudharyN.AnjankarA

Tab 5: ER-resident protein list used in Fig

Ketone Body Metabolism: Ketogenesis and Ketolysis The classic ratio of fat to carbohydrate plus protein in the KD is 3:1 or 4:1, in which 8090% of total calories comes from fats, 4% from carbohydrates and 6% from proteins