if nothing is blocked, you just create chaos and total ATP can actually drop He tells a story of a client who tried just 0.5 to 1 mg, felt way worse with more anxiety and fatigue, and later testing showed his mitochondria were not the type that benefited, so methylene blue just sabotaged him Aging as slow mitochondrial damage Chris says he sees mitochondrial dysfunction and aging as the same process, just described in different languages like oxidative stress or information theories From around 18 to 7080, people lose mitochondrial function about 1% per year on average by the time youre 70, you have half the energy that you started out with at baseline He thinks this comes from cumulative insults: infections, injuries, bad diet periods, and overtraining phases where your mitochondria spend slightly more energy supporting you and slightly less repairing themselves Each tiny 0.25 or 0.5 percent hit compounds into a vicious cycle where weaker mitochondria repair themselves even less, and the decline speeds up The good news is that age only explains about a quarter of mitochondrial function variance, meaning roughly 75% is under lifestyle control 5 big levers for your mitochondria Everyone has unique quirks that show up best with mitochondrial testing, but if he has to pick 5 universal levers , it is creatine, sunlight, nutrition, exercise, and skillful full-body movement Creatine specifics: Everyone whos not eating one or two pounds of meat per day should probably be taking creatine. One pound is enough if it is rare red meat and salmon, closer to two pounds if it is white meat and well done, because you lose creatine, and there is less to start with For vegans, he jokes you would need around half a kilo of tofu plus half a kilo of quinoa daily to match it, which is not realistic for most guts, so just take creatine (we use Momentous, which you can get here) Sunlight lever: Mitochondria wake up when morning light hits your eyes and brain, so skipping morning light keeps you in a kind of sluggish, suboptimal energy mode that feeds aging Morning is best for red/infrared with low burn risk, so you can soak that for an hour or two if your life allows, then layer in devices if you need more Nutrition basics: Surveys show more than 90% of people are low on at least one nutrient, and a meaningful chunk have blood markers of real deficiencies, so we solved deficiencies is a myth Eat animals nose to tail when you can: liver, heart, bones, broth, not just chicken breast and ground beef Rotate protein sources: shellfish, fish, dairy, red meat if tolerated, because each gives a different micronutrient mix Aim for at least a third of your plate as protein, and with eggs and dairy, you probably need more volume because they are lower in protein density per plate Eat plenty of whole-food carbs from different sources, and if you need to cut something, he would cut grains first
An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
The generalizability of findings to diverse populations needs further validation
Another study found that the EAT secretome of AF patients had proinflammatory and profibrotic effects that intensified with AF progression, and that this EAT was enriched with neutrophils, which secrete numerous profibrotic molecules such as myeloperoxidase [125]
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