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This shows that hypertension leads to iron overload in the brain, and iron overload increases OS and lipid peroxidation, thereby causing ferroptosis (Yang et al., 2020) in neurons and ultimately leading to brain injury (Figure 2)

As DAMPs, these secreted factors activate the apoptotic pathway and autophagy and induce oxidative stress, and the antioxidant mechanism cannot be restored before apoptosis and ferroptosis are induces [228]

neoformans as a fungal pathogen of critical importance by the World Health Organization highlights the urgent need to explore the devastating disease caused by this organism a disease with limited treatment options and no vaccine 12,13

doi: 10.2337/db09-0942 42 LiBLeungJCKChanLYYYiuWHTangSCW

The ink is sequestered in their vacuoles

Based on our observations, we provide guidelines for future investigations of eryptosis in malaria in vitro studies