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Compared to the NT treatment, the HT treatment significantly decreased P 0 (from 2.415 (NT) to 1.033 mol CO 2 m 2 s 1 (HT)), P max (from 26.61 (NT) to 8.58 mol CO 2 m 2 s 1 (HT)) and (from 0.0794 (NT) to 0.0194 (HT)) (Table 2)

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When ARA-290 binds to the IRR, it does two critical things: It shuts down inflammation: It tells the immune system to stop attacking the damaged area, switching the focus from "defense" to "reconstruction." It stimulates regeneration: It promotes the sprouting of small nerve fibers, which are often the first to die in conditions like Small Fiber Neuropathy (SFN)

It enhances anti-inflammatory/antibacterial capacity in IPECs and upregulates Claudin-1, EGFR, and IL-10 gene expression ( CB s anti-inflammatory effect exhibits gender heterogeneity in high-fat diet (HFD)-induced Fischer-344 rats ( 3.1.3 Regulate innate immune cell function Besides butyrate-mediated pathways, Clostridium ( FP , CB ) and their derivatives (extracellular matrix [EPM], EVs) directly regulate innate immune cells ( in vitro experiments have clarified the cell type-specific regulatory mechanisms