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First, although GPER has been extensively studied in animal models (mice and rats), the phenotypes observed in these models may not fully replicate those observed in humans, thereby limiting the generalizability of the findings

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Mimics and models of glutathione peroxidase 2.1 Ebselen analogues as GPx mimics/models Synthetic selenium compounds with significant GPx activity have potential therapeutic applications (Figure 3)

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reducing glomerular mesangial cell proliferation by blocking the mitogen-activated protein kinase (MAPK) signaling pathway

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